User's guide: Programs for processing altimeter data over inland seas

The programs described were developed to process GEODYN-formatted satellite altimeter data, and to apply the processed results to predict geoid undulations and gravity anomalies of inland sea areas. These programs are written in standard FORTRAN 77 and are designed to run on the NSESCC IBM 3081(MVS) computer. Because of the experimental nature of these programs they are tailored to the geographical area analyzed. The attached program listings are customized for processing the altimeter data over the Black Sea. Users interested in the Caspian Sea data are expected to modify each program, although the required modifications are generally minor. Program control parameters are defined in the programs via PARAMETER statements and/or DATA statements. Other auxiliary parameters, such as labels, are hard-wired into the programs. Large data files are read in or written out through different input or output units. The program listings of these programs are accompanied by sample IBM job control language (JCL) images. Familiarity with IBM JCL and the TEMPLATE graphic package is assumed

Analysis of altimetry over inland seas

Satellite-based altimetric data taken by GEOS-3 and SEASAT over the Black Sea and Caspian Sea are analyzed and a least squares collocation technique is used to predict the geoid undulation on a .25-degree by .25-degree grid and to transform these geoid undulations to free air gravity anomalies. This project entailed processing satellite altimeter data over inland seas for recovery of area mean gravity information. Gravity information in this area of the world is not readily available, so the possibility of obtaining it from the processing of altimeter observations is attractive. The principal objective was to complete and extend analyses done in a previous study, verify those results, and document the results and techniques. A secondary objective was to improve the algorithms and results, if possible. The approach used involved editing geoid height data to remove overland data; evaluating geoid height differences at crossover points; removing orbit errors from geoid heights using crossover differences; gridding geoid height data at .25-degree by .25-degree intervals; and estimating the gravity anomalies from gridded geoid heights using the collocation technique

Duality and Symmetry in Chiral Potts Model

We discover an Ising-type duality in the general $N$-state chiral Potts model, which is the Kramers-Wannier duality of planar Ising model when N=2. This duality relates the spectrum and eigenvectors of one chiral Potts model at a low temperature (of small $k'$) to those of another chiral Potts model at a high temperature (of $k'^{-1}$). The $\tau^{(2)}$-model and chiral Potts model on the dual lattice are established alongside the dual chiral Potts models. With the aid of this duality relation, we exact a precise relationship between the Onsager-algebra symmetry of a homogeneous superintegrable chiral Potts model and the $sl_2$-loop-algebra symmetry of its associated spin-$\frac{N-1}{2}$ XXZ chain through the identification of their eigenstates.Comment: Latex 34 pages, 2 figures; Typos and misprints in Journal version are corrected with minor changes in expression of some formula

An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors

© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Purpose The immune checkpoint inhibitors (ICIs) have resulted in subgroups of patients with metastatic melanoma achievinghigh-quality durable responses. Metastatic melanoma survivors are a new population in the era of cancer survivorship. The aimofthis study was to evaluate metastatic melanoma survivors in terms of health-related quality of life (HRQoL), immune-relatedadverse events (irAEs) and exposure to immunosuppressive agents in a large single centre in the UK.Methods We defined the survivor population as patients with a diagnosis of metastatic melanoma who achieved a durableresponse to an ICI and had been followed-up for a minimum of 12 months from initiation of ICI without disease progression.HRQoL was assessed using SF-36. Electronic health records were accessed to collect data on demographics, treatments, irAEsand survival. HRQoL data was compared with two norm-based datasets.Results Eighty-four metastatic melanoma survivors were eligible and 87% (N = 73) completed the SF-36. ICI-related toxicity ofany grade occurred in 92%of patients and 43%had experienced a grade 3 or 4 toxicity. Almost half (49%) of the patients requiredsteroids for the treatment of ICI-related toxicity, whilst 14% required treatment with an immunosuppressive agent beyondsteroids.Melanoma survivors had statistically significant lower HRQoL scores with regard to physical, social and physical rolefunctioning and general health compared with the normative population. There was a trend towards inferior scores in patientswith previous exposure to ipilimumab compared with those never exposed to ipilimumab.Conclusions Our results show that metastatic melanoma survivors have potentially experienced significant ICI-related toxicityand experience significant impairments in specific HRQoL domains. Future service planning is required to meet this population’sunique survivorship needs.Peer reviewe

Investigation of shock waves in the relativistic Riemann problem: A comparison of viscous fluid dynamics to kinetic theory

We solve the relativistic Riemann problem in viscous matter using the relativistic Boltzmann equation and the relativistic causal dissipative fluid-dynamical approach of Israel and Stewart. Comparisons between these two approaches clarify and point out the regime of validity of second-order fluid dynamics in relativistic shock phenomena. The transition from ideal to viscous shocks is demonstrated by varying the shear viscosity to entropy density ratio $\eta/s$. We also find that a good agreement between these two approaches requires a Knudsen number $Kn < 1/2$.Comment: Version as published in PRC 82, 024910 (2010); 16 pages, 16 figures, typos correcte

A wideband linear tunable CDTA and its application in field programmable analogue array

This document is the Accepted Manuscript version of the following article: Hu, Z., Wang, C., Sun, J. et al. ‘A wideband linear tunable CDTA and its application in field programmable analogue array’, Analog Integrated Circuits and Signal Processing, Vol. 88 (3): 465-483, September 2016. Under embargo. Embargo end date: 6 June 2017. The final publication is available at Springer via https://link.springer.com/article/10.1007%2Fs10470-016-0772-7 © Springer Science+Business Media New York 2016In this paper, a NMOS-based wideband low power and linear tunable transconductance current differencing transconductance amplifier (CDTA) is presented. Based on the NMOS CDTA, a novel simple and easily reconfigurable configurable analogue block (CAB) is designed. Moreover, using the novel CAB, a simple and versatile butterfly-shaped FPAA structure is introduced. The FPAA consists of six identical CABs, and it could realize six order current-mode low pass filter, second order current-mode universal filter, current-mode quadrature oscillator, current-mode multi-phase oscillator and current-mode multiplier for analog signal processing. The Cadence IC Design Tools 5.1.41 post-layout simulation and measurement results are included to confirm the theory.Peer reviewedFinal Accepted Versio

Regge calculus from a new angle

In Regge calculus space time is usually approximated by a triangulation with flat simplices. We present a formulation using simplices with constant sectional curvature adjusted to the presence of a cosmological constant. As we will show such a formulation allows to replace the length variables by 3d or 4d dihedral angles as basic variables. Moreover we will introduce a first order formulation, which in contrast to using flat simplices, does not require any constraints. These considerations could be useful for the construction of quantum gravity models with a cosmological constant.Comment: 8 page

The Chiral Potts Models Revisited

In honor of Onsager's ninetieth birthday, we like to review some exact results obtained so far in the chiral Potts models and to translate these results into language more transparent to physicists, so that experts in Monte Carlo calculations, high and low temperature expansions, and various other methods, can use them. We shall pay special attention to the interfacial tension $\epsilon_r$ between the $k$ state and the $k-r$ state. By examining the ground states, it is seen that the integrable line ends at a superwetting point, on which the relation $\epsilon_r=r\epsilon_1$ is satisfied, so that it is energetically neutral to have one interface or more. We present also some partial results on the meaning of the integrable line for low temperatures where it lives in the non-wet regime. We make Baxter's exact results more explicit for the symmetric case. By performing a Bethe Ansatz calculation with open boundary conditions we confirm a dilogarithm identity for the low-temperature expansion which may be new. We propose a new model for numerical studies. This model has only two variables and exhibits commensurate and incommensurate phase transitions and wetting transitions near zero temperature. It appears to be not integrable, except at one point, and at each temperature there is a point, where it is almost identical with the integrable chiral Potts model.Comment: J. Stat. Phys., LaTeX using psbox.tex and AMS fonts, 69 pages, 30 figure

Magnetic Dipole Sum Rules for Odd-Mass Nuclei

Sum rules for the total- and scissors-mode M1 strength in odd-A nuclei are derived within the single-j interacting boson-fermion model. We discuss the physical content and geometric interpretation of these sum rules and apply them to ^{167}Er and ^{161}Dy. We find consistency with the former measurements but not with the latter.Comment: 13 pages, Revtex, 1 figure, Phys. Rev. Lett. in pres

Bethe Ansatz Equations for the Broken ZNZ_{N}-Symmetric Model

We obtain the Bethe Ansatz equations for the broken ${\bf Z}_{N}$-symmetric model by constructing a functional relation of the transfer matrix of $L$-operators. This model is an elliptic off-critical extension of the Fateev-Zamolodchikov model. We calculate the free energy of this model on the basis of the string hypothesis.Comment: 43 pages, latex, 11 figure